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Biology

NSWBiologyExam trends

Biology exam trends & analysis (2019–2025)

Across 2019-2025 the four modules are examined remarkably evenly (Module 6 Genetic Change leads with 199 marks, followed by Module 8 Non-infectious Disease (177), Module 7 Infectious Disease (163) and Module 5 Heredity (161)). By topic, meiosis and reproduction is by far the most examined dot point, then homeostasis/feedback and epidemiology; immune response, biotechnology applications, mutation types and mutation-and-evolution also recur in every paper.

Based on 303 questions across 7 official NESA exam papers, their marking guidelines and marking feedback.

Work in progress

These exam-trend insights are an early release. The frequencies, mark ranges and figures are still being verified against the official NESA past papers and may change. Treat them as a study guide, not a guarantee of what will be examined.

Most-examined dot points

By module

Module 5
Heredity
79 questions
161 marks total
Module 6
Genetic Change
81 questions
199 marks total
Module 7
Infectious Disease
71 questions
163 marks total
Module 8
Non-infectious Disease and Disorders
72 questions
177 marks total

Every dot point, by exam frequency

Click any dot point for the full verbatim syllabus wording, worked answers and past questions.

Showing 34 of 34 dot points

Dot pointTimesMarks
Meiosis and gamete formation explainedM5

Give specific detail on meiosis and fertilisation, not general info; know meiosis (not mitosis) produces gametes

36×1–6
Homeostasis, feedback, thermoregulation and osmoregulationM8

Use precise terms (vasodilation, hypothalamus, evaporative cooling) not general descriptions; understand the hypothalamus detects internal temperature and sweat evaporation cools the skin

23×1–6
Epidemiology: incidence, prevalence, mortality and study designsM8

Discuss data beyond repeating the table, identify dominant/recessive alleles, and write clearly and succinctly

18×1–7
Biotechnology applications in agriculture, medicine and industryM6

Show cause and effect; use quantitative data; link the benefit to aquaculture

16×1–7
Types of mutation: point, silent, frameshift and chromosomalM6

Present information concisely, interpret the table requirements, and understand each mutation type's effect on offspring

16×1–4
Local, regional and global strategies to limit disease spreadM7

Interpret different data types to identify trends, link trends to the data, and use terms like incidence/distribution correctly

14×1–7
Mutation, gamete variation and the source of new allelesM6

Use specific DNA and evolution detail; refer to natural selection, not Lamarckian inheritance

14×1–7
Antivirals, antibiotics, resistance and immunisationM7

Mismatched drug to pathogen (antibiotics on viruses); confused antibiotics with antibodies; said the body, not bacteria, develops resistance

13×1–7
Technologies for hearing and vision disordersM8

Provide a clear key per ear; read the dB axis; plot precisely

13×1–5
Transcription and translation explainedM5

Demonstrate clear understanding of both transcription and translation

13×1–5
Causes of infectious disease and pathogen typesM7

Lacked specificity (single-stranded RNA, not just single-stranded); classified by processes not structures

12×1–3
Adaptive immune response, humoral and cell-mediated immunityM7

Just described the graphs without applying syllabus knowledge of vaccination, immunity and antibody action

11×1–8
Effects of mutation on amino acid sequence: coding vs non-coding DNAM6

Use the stimulus and link the mutation to a changed structure then loss of cell-division control; understand uncontrolled division causes cancer

11×1–4
Recombinant DNA, CRISPR, whole genome sequencing and gene therapyM6

Used general statements grouping diseases/technologies; lacked genetic-level detail; confused genetic technology with biotechnology

10×1–7
DNA replication explainedM5

Understand replication yields two semiconservative molecules, each with one parent strand

1–3
Codominance, incomplete dominance and multiple alleles explainedM5

Provide an appropriate key to aid interpretation of the Punnett squares

1–5
Pedigree analysis for mutationsM6

Make a definitive statement; a single band means homozygous; not probability/Punnett

1–3
Disease management: pharmaceuticals, gene therapy, lifestyleM8

Did not use the full grid with an appropriate, evenly divided scale

1–3
Koch and Pasteur, and Koch's postulatesM7

Apply biological knowledge to the situation using flowcharts

1–5
Punnett squares and Mendelian inheritanceM5

Distinguish allele from genotype and use all stem information to determine allele combinations

1–3
Causes of non-infectious diseaseM8

Specifically define disease categories (not just 'not caused by a pathogen') and use data and examples from all parts of Q33 to support the judgement

1–8
Innate immune response in animals, first and second lines of defenceM7

Lacked precise terminology such as 'engulf' or 'enclose'

1–2
DNA structure: Watson, Crick, Franklin and WilkinsM5

Answer about DNA/chromosome structure, not location or general cell differences

1–3
Effects of biotechnology on biodiversityM6

Use terminology specific to biodiversity and biotechnology and give specific examples rather than general comments

2–9
Modes of disease transmissionM7

Address the plural 'diseases' by giving more than one disease example

1–3
Prevention of non-infectious diseaseM8

Use specific real educational programs as examples (more than one), not screening programs, genetic testing or legislation

3–6
Sex-linked inheritance explainedM5

Poor use of formats (Punnett squares); limited understanding of autosomal versus sex-linked inheritance

1–4
Causes of mutation: physical, chemical and biological mutagensM6

Did not distinguish gametic from somatic mutations; unclear which radiation causes DNA damage

1–2
Nutritional and environmental diseasesM8

Named a pathogen/genetic disease instead of environmental; gave a symptom not a cause

1–2
Pathogen adaptations for entry and transmissionM7

Name a specific pathogen (not a disease) and distinguish entry adaptations from immune-evasion or transmission adaptations

2
Plant responses to pathogens, physical and chemical defencesM7

Failed to name a plant disease; stated 'has an impact' without a directional effect on agriculture

1–4
Aboriginal protocols and the development of medicinesM7
Future directions of genetic research: germline editing, gene drives and synthetic biologyM6
Genetic disorders: cystic fibrosis, sickle cell, Huntington'sM8