Quick questions on Pathogen adaptations for entry and transmission: HSC Biology Module 7

Many pathogens carry surface molecules that bind to specific host cell receptors. Influenza haemagglutinin binds to sialic acid on respiratory cells. HIV gp120 binds to CD4 receptors on T helper cells.

Streptococcus pyogenes produces hyaluronidase and streptokinase, which break down connective tissue and clot proteins, allowing the bacterium to spread through skin and soft tissue. Some fungi secrete keratinases to digest skin.

Bacteriophages and many bacterial pathogens use pili and fimbriae to attach to host cells before invasion. Salmonella uses a type III secretion system, a needle-like structure, to inject proteins that force gut cells to engulf the bacterium.

Bacillus anthracis forms endospores that resist heat, drying and chemical insult, allowing the pathogen to remain infectious in soil for decades. Giardia lamblia forms tough cysts that survive in water until ingested.

Influenza and HIV mutate rapidly (antigenic drift) so that antibodies raised against earlier strains do not recognise new ones. Trypanosoma brucei changes its surface glycoprotein coat repeatedly, evading antibody recognition.

Streptococcus pneumoniae has a polysaccharide capsule that prevents phagocytosis. Pseudomonas aeruginosa forms biofilms that block antibiotics and immune cells.

Viruses replicate inside host cells, hidden from antibodies. Mycobacterium tuberculosis survives inside macrophages, the very cells meant to destroy it.

Plasmodium has separate stages for the mosquito and human host, with surface proteins matching each. The parasite manipulates mosquito feeding behaviour to favour transmission.

Norovirus is non-enveloped and resists drying, surviving on surfaces for weeks. Prions resist boiling, UV and standard disinfection, allowing transmission via contaminated surgical instruments.

Measles virus produces enormous numbers of virions in the airway, and an infected person typically infects 12 to 18 susceptibles in a fully susceptible population.

"It has proteins on its surface" earns no marks. Name the protein (haemagglutinin, gp120, pili) and the receptor it binds.

If asked to "compare adaptations", cover entry, evasion and transmission deliberately rather than listing random features - it shows the marker you understand the categories.

"Outline" wants brief points; "compare" wants the same features set against both pathogens; "assess/evaluate" wants a justified judgement (e.g. transmission mode is the main selective pressure shaping the adaptations).

Airborne pathogens favour aerosolisation and antigenic change; vector-borne pathogens favour multi-stage life cycles; faecal-oral pathogens favour durable or symptom-driven shedding. Linking adaptation to mode earns the higher-order marks.